Vehicular Relaxation And Amphan Cyclone: Is It A Double Threat To India Towards Combat Of COVID-19

The COVID-19 spread as a pandemic and more than 185 countries have suffered from it. Various strategies have been devised to combat the virus and prevent it from spreading. In India, lockdown had been initiated since 24th March 2020 and social gatherings had been restricted. But due to the slump in the economy and to boost up trade, certain manufacturing sectors have been opened and vehicular movement was relaxed. PM2.5 and NO2 levels started to rise drastically, which were initially reduced during the lockdown. Moreover, the recent Amphan super cyclonic storm may have increased the risk of COVID spread. A statistical Spearman correlation analysis of the air quality index (AQI) parameters with meteorological variables was carried out to ascertain the significance. Detailed epidemiological studies are warranted to confirm the spike in COVID positive cases may have been related to unforeseen torrential rains as a result of Amphan the cyclone and increased vehicular pollution. © 2021 - Kalpana Corporation

Activity of Isoxazole substituted 9-aminoacridines against SARS CoV-2 main protease for COVID19: A computational approach

Coronavirus Disease 2019 (COVID-19), a life-threatening viral disease affected first in china and quickly spread throughout the world in early 2020. So many scientists are rushing to discover novel drugs and vaccines against the coronavirus, and treatments for COVID-19.In the present article, in-silico studies have been performed to explore the binding modes of Isoxazole substituted 9-aminoacridines(1a-x) against SARS CoV-2 main protease (PDB id-5R82) targeting corona virus using Schrodinger suit 2019-4. The docking studies are performed by Glide module, in-silico ADMET screening was performed by qik prop module and the binding energy of ligands was calculated using PRIME MM-GB/SA module. From the results, Isoxazole substituted 9-aminoacridines like 1n,f,c,k,h,a,e,g,b,d are significantly active against SARS CoV-2 main protease with Glide score more than-5.5 when compared with currently recommended drug for COVID19 Hydroxy chloroquine (G score-5.47) and Co crystallized ligand CID_24701445 (G score-4.4). The docking results of the compounds exhibited similar mode of interactions with COVID19 and the residues THR24, THR25, THR26, SER46, MET49, HIE41, GLN189, ARG189, ASP187, MET168, HIE164, ASN142 and GLY143 play a crucial role in binding with ligands. © 2021 DSR Publishers/The University of Jordan. All Rights Reserved.

Compare the vital concepts of mother of all pandemic Spanish flu and COVID-19: A promising review

In every century, few invisible infectious diseases create an alarm to the entire world and which leads to extermination of the population. In 1918 and 2019, the world has tackled truculent diseases such as mother of all pandemic Spanish flu and COVID 19. The mortality rate of Spanish flu was greater than in the first world war. After 100 years’ same history was repeated in 2019 through COVID 19. Suddenly a huge number of pneumonia cases were reported in the end of 2019 in Wuhan, China. These two outbreaks make medical, social and financial burden to the entire world. This kind of sudden pandemic breaks mental health and creates panic, anxiety and depression. Pharmaceutical preventive measures are not supported during both pandemics which was rectified by non-pharmaceutical preventive steps like lockdown, quarantine, wearing facemask and gloves, washing hands and applying sanitizer, follow the social distancing, closing cinema hall and schools, avoiding mass gathering in 1918and 2019-2020. The main objective of this review is to compare and summarize the concepts of both pandemics and how the people of the world need to come together and fight against common enemies, to warrant that we have the best scientific resources necessary to bring this outbreak to an end. © 2020 Ubiquity Press. All rights reserved.

Activity of thiazine substituted 9-anilinoacridines against corona virus (Covid19): An in-silico approach

Coronavirus Disease 2019 (COVID-19), a life-threatening viral disease affected first in Wuhan, China, and quickly spread to more than 200 countries in the world in the year 2020. So many scientists are trying to discover novel drugs and vaccines for coronavirus and treatment for COVID-19. In the present arti-cle, in-silico studies have been performed to explore the binding modes of Thiazine substituted 9-anilinoacridines (1a-z) against SARS CoV 2 main protease (PDB id-5R82) targeting the coronavirus using Schrodinger suit 2019-4. The molecular docking studies are performed by Glide module, in-silico ADMET screening was performed by Qik prop module, and the binding free energy of ligands was calculated using PRIME MM-GB/SA module of Schrodinger suite 2019-4, Maestro 21.2 version. From the in-silico results, Thiazine substituted 9-anilinoacridines like 1m, 1j, 1s and 1b are significantly active against SARS CoV 2 main protease with Glide score more than-5.4 when compared with the currently recommended drug for COVID19, Hydroxychloroquine (G score-5.47). The docking results of the Thiazine substituted 9-anilinoacridines exhibited similar mode of interactions with COVID19 and the residues GLN19, THR24, THR25, THR26, LEU27, HIE41, SER46, MET49, ASN142, GLN143, HIE164, MET165, ASP187, ARG188 and GLN189, play a crucial role in binding with ligands. © International Journal of Research in Pharmaceutical Sciences.